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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fuerlinger, A; Stockner, A; Sedej, S; Abdellatif, M.
Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential.
Cardiovasc Diabetol. 2025; 24(1): 21
Doi: 10.1186/s12933-024-02566-8
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- Leading authors Med Uni Graz
- Abdellatif Mahmoud
- Fürlinger Alexander
- Co-authors Med Uni Graz
- Sedej Simon
- Stockner Alina
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- Abstract:
- The global increase in human life expectancy, coupled with an unprecedented rise in the prevalence of obesity, has led to a growing clinical and socioeconomic burden of heart failure with preserved ejection fraction (HFpEF). Mechanistically, the molecular and cellular hallmarks of aging are omnipresent in HFpEF and are further exacerbated by obesity and associated metabolic diseases. Conversely, weight loss strategies, particularly caloric restriction, have shown promise in improving health status in patients with HFpEF and are considered the gold standard for promoting longevity and healthspan (disease-free lifetime) in model organisms. In this review, we implicate fundamental mechanisms of aging in driving HFpEF and elucidate how caloric restriction mitigates the disease progression. Furthermore, we discuss the potential for pharmacologically mimicking the beneficial effects of caloric restriction in HFpEF using clinically approved and emerging caloric restriction mimetics. We surmise that these compounds could offer novel therapeutic avenues for HFpEF and alleviate the challenges associated with the implementation of caloric restriction and other lifestyle modifications to reduce the burden of HFpEF at a population level.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Caloric Restriction - administration & dosage
- Heart Failure - physiopathology, metabolism, drug therapy, diet therapy, therapy
- Stroke Volume - drug effects
- Animals - administration & dosage
- Ventricular Function, Left - drug effects
- Treatment Outcome - administration & dosage
- Energy Metabolism - drug effects
- Recovery of Function - administration & dosage
- Age Factors - administration & dosage
- Aging - metabolism
- Obesity - physiopathology, metabolism, drug therapy, therapy
- Find related publications in this database (Keywords)
- Aging
- HFpEF
- Obesity
- Fasting
- Caloric restriction mimetics
- SGLT2
- GLP-1A