Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Parhizkar, P; Yaghini, J; Fakheran, O.
Patient-Reported Outcomes Following Systemic Antibiotic Adjunct to Nonsurgical Treatment of Periodontitis: A Randomized Controlled Clinical Trial.
Clin Exp Dent Res. 2025; 11(1):e70067
Doi: 10.1002/cre2.70067
[OPEN ACCESS]
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Fakheran Esfahani Omid
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- Abstract:
- OBJECTIVES: Considering the importance of patient-centered care, we aimed to evaluate the impact of systemic antibiotics on oral health-related quality of life during nonsurgical periodontal treatment. This controlled trial addresses a gap in understanding how systemic antibiotics influence patient-reported outcomes, focusing on Stage III periodontitis. MATERIALS AND METHODS: Sixty-one adults participated in a double-blind, randomized clinical trial, with participants divided into two groups: the test group, which received antibiotics, and the control group. All the participants received nonsurgical periodontal treatment. We conducted follow-up assessments at one and 3 months posttreatment, including recording clinical parameters and administering the Oral Health Impact Profile-14 (OHIP-14) questionnaire. RESULTS: The results showed a notable improvement in the quality of life for patients in the test group compared to the control group at 1 month (p value = 0.012) and 3 months (p value = 0.014) after treatment. While there were improvements in pocket probing depth, gingival index, and clinical attachment loss in both groups, it is worth noting that only bleeding on probing exhibited a significant improvement in the test group after 3 months compared to the control group (p value = 0.008). CONCLUSIONS: In summary, incorporating systemic antibiotics alongside nonsurgical periodontal treatments appears to bring about positive outcomes for individuals dealing with Stage III periodontitis during nonsurgical treatment, ultimately enhancing their oral health-related quality of life. TRIAL REGISTRATION: Iranian Registry of Clinical Trials (IRCT Id): IRCT20201221049786N1.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Quality of Life - administration & dosage
- Anti-Bacterial Agents - therapeutic use, administration & dosage
- Double-Blind Method - administration & dosage
- Patient Reported Outcome Measures - administration & dosage
- Adult - administration & dosage
- Middle Aged - administration & dosage
- Periodontitis - drug therapy, therapy
- Treatment Outcome - administration & dosage
- Periodontal Index - administration & dosage
- Dental Scaling - administration & dosage
- Oral Health - administration & dosage
- Surveys and Questionnaires - administration & dosage
- Find related publications in this database (Keywords)
- antibiotic
- health-related quality of life (HRQOL)
- periodontitis