Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Barwig, M; Janisch, M; Gessl, J; Kübler, W; König, C; Schwantzer, G; Schöllnast, H.
Efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography.
Insights Imaging. 2025; 16(1): 13 Doi: 10.1186/s13244-024-01892-5 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Schoellnast Helmut
Co-Autor*innen der Med Uni Graz: Janisch Michael August Johann; Kübler Wolfgang Josef; Schwantzer Gerold
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Abstract:: PURPOSE: To assess the efficacy of bolus injections of landiolol hydrochloride as premedication in coronary artery CT angiography (CCTA). METHODS: The study population consisted of 37 patients (17 female; median age, 56 years; IQR, 19 years; range, 19-88 years) who underwent CCTA after intravenous injection of landiolol hydrochloride due to a heart rate > 60 bpm. Landiolol hydrochloride was administered in a stepwise manner until a heart rate of ≤ 60 bpm was achieved or a maximum dose of 60 mg was reached after six injections. Heart rates routinely displayed continuously on the CT scanner before the start of the landiolol hydrochloride injection (HR_PRE), after each partial dose (HR_1-6), during the CT scan (HR_CT), and after the examination before moving from the CT table (HR_POST) were recorded. Furthermore, the blood pressure routinely measured before (BP_PRE) and after the examination before moving from the CT table (BP_POST) was recorded. RESULTS: A HR_CT of ≤ 60 bpm was achieved in 13 patients (35%) and a HR_CT ≤ 65 bpm was achieved in 25 patients (68%). The mean difference (± SD) between HR_PRE and HR_CT was -11 ± 9 bpm in total, -14 ± 10 bpm in patients without oral beta-blocker premedication and -6 ± 5 bpm in patients with oral Beta-blocker premedication. CONCLUSIONS: Landiolol hydrochloride enables a reduction of the heart rate in patients with and without oral beta-blocker premedication, whereby the use of serial partial doses is a simple and effective approach in clinical routine. CRITICAL RELEVANCE STATEMENT: In cardiac CT, weight-independent, stepwise landiolol hydrochloride injection up to 40 mg reduces heart rate by -14 bpm without and -5 bpm with oral beta-blocker premedication, and achieves heart rates of ≤ 65 bpm in a significant proportion of patients. KEY POINTS: The ideal heart rate for cardiac CT is ≤ 60-65 bpm, which improves image quality and reduces radiation dose. In cardiac CT, landiolol hydrochloride intravenously reduces heart rate by -14 bpm. Heart rate of ≤ 65 bpm can be achieved in a significant proportion of patients.
Find related publications in this database (Keywords): Multidetector computed tomography; Cardiac imaging techniques; Beta-adrenergic blocker; Heart-drug effects; Heart rate