Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Roohani, S; Handtke, J; Hummedah, K; Albertsmeier, M; Andreou, D; Apostolidis, L; Augustin, M; Bauer, S; Billner, M; Bösch, F; Deinzer, CKW; Deventer, N; Duprée, A; Eckert, F; Engel, L; Fechner, K; Fritzsche, H; Gaidzik, V; Ghani, S; Grützmann, R; Guder, WK; Hamacher, R; Hecker, JS; Hendricks, A; Hillmann, A; Houben, P; Hübner, G; Ivanyi, P; Jentsch, C; Jordan, M; Kappl, P; Kaths, M; Kessler, T; Kirchberg, J; Knebel, C; Krempien, R; Lehner, B; Lenze, U; Lindner, LH; Lörsch, AM; Maguire, N; Müller, S; Piso, P; Potkrajcic, V; Reichardt, P; Richter, S; Schewe, S; Schiffmann, LM; Scholten, F; Striefler, JK; Schwarzbach, M; Seidensaal, K; Semrau, S; Szkandera, J; Szuszies, CJ; Timmermann, B; Tuscherer, A; Wiegering, A; Winkelmann, MT; Kaul, D; Jakob, J.
The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers.
J Cancer Res Clin Oncol. 2025; 151(1): 30
Doi: 10.1007/s00432-024-06063-z
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- Co-Autor*innen der Med Uni Graz
- Andreou Dimosthenis
- Szkandera Joanna
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- Abstract:
- PURPOSE: The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study investigated the variability in treatment recommendations for localized STS across different German-speaking tertiary sarcoma centers. METHODS: In this cross-sectional case-based survey study, 5 anonymized patient cases with imaging data of localized STS were presented to MTBs of 21 German-speaking tertiary referral hospitals. Centers provided recommendations on treatment sequence and modalities, along with the consensus level within their MTB. Agreement percentages were calculated, and consensus levels were rated on a scale of 1 to 10. RESULTS: Five patient cases were discussed resulting in 105 recommendations. Agreement percentages for case 1 to 5 were 14.3%, 61.9%, 33.3%, 52.4% and 9.3%, with a median agreement percentage of 33.3%. Grouping pre- and postoperative therapies as "perioperative" and including recommendations with and without regional hyperthermia raised the median agreement to 47.6%. The mean consensus level within each center across all 5 cases was 9.5. CONCLUSION: This first case-based analysis of inter-center agreement for STS management in German-speaking countries reveals low inter-center agreement but high intra-center consensus. Our study includes nearly all tertiary sarcoma centers in German-speaking countries, affirming its strong external validity. These findings suggest potential and clinically very relevant differences in treatment standards among sarcoma centers. Enhanced case-based exchanges and collaborative efforts are needed to reduce discrepancies and standardize the management of STS patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Sarcoma - therapy, pathology
- Cross-Sectional Studies - administration & dosage
- Germany - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Adult - administration & dosage
- Tertiary Care Centers - administration & dosage
- Aged - administration & dosage
- Find related publications in this database (Keywords)
- Soft tissue sarcoma
- Ring trial
- Reference center
- Inter-center agreement
- German Cancer Society
- Guidelines