Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Derks, W; Rode, J; Collin, S; Rost, F; Heinke, P; Hariharan, A; Pickel, L; Simonova, I; Lázár, E; Graham, E; Jashari, R; Andrä, M; Jeppsson, A; Salehpour, M; Alkass, K; Druid, H; Kyriakopoulos, CP; Taleb, I; Shankar, TS; Selzman, CH; Sadek, H; Jovinge, S; Brusch, L; Frisén, J; Drakos, S; Bergmann, O.
A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.
Circulation. 2024;
Doi: 10.1161/CIRCULATIONAHA.123.067156
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- Co-authors Med Uni Graz
- Andrä Michaela
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- Abstract:
- BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. METHODS: We determined cardiomyocyte renewal in 52 patients with advanced heart failure, 28 of whom received left ventricular assist device support. We measured the concentration of nuclear bomb test-derived 14C in cardiomyocyte genomic DNA and performed mathematical modeling to establish cardiomyocyte renewal in heart failure with and without LVAD unloading. RESULTS: We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18 to 50× lower compared with the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. CONCLUSIONS: Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.
- Find related publications in this database (Keywords)
- myocytes, cardiac
- heart failure
- heart-assist device
- polyploidy
- regeneration