Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pušeljić, M; Stadlbauer, V; Ahmadova, N; Pohl, M; Kopetzky, M; Kaufmann-Bühler, AK; Watzinger, N; Igrec, J; Fuchsjäger, M; Talakić, E.
Impact of body fat composition on liver iron overload severity in hemochromatosis: a retrospective MRI analysis.
Radiol Med. 2025; 130(2):179-189
Doi: 10.1007/s11547-024-01930-8
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- Führende Autor*innen der Med Uni Graz
- Puseljic Marijan
- Talakic Emina
- Co-Autor*innen der Med Uni Graz
- Fuchsjäger Michael
- Igrec Jasminka
- Kaufmann-Bühler Ann-Katrin
- Kopetzky Michaela
- Pohl Maximilian
- Stadlbauer-Köllner Vanessa
- Watzinger Nikolaus
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- Abstract:
- PURPOSE: To evaluate the correlation between ectopic adipose tissue and iron overload severity in patients with hemochromatosis. MATERIAL AND METHODS: A retrospective cohort of 52 patients who underwent liver iron concentration quantification from January 2015 to October 2023 using a 3.0T MRI scanner. R2* relaxation times and proton density fat fraction (PDFF) were assessed for the entire liver volume and a specific region of interest (ROI) placed in the right lobe. Total body fat (TF), subcutaneous fat (SCF), intermuscular fat (IMF), and visceral fat (VSF) percentages were calculated from a single axial slice at the level of the third lumbar vertebra. Additionally, ratios of IMF-to-VSF, IMF-to-SCF, and SCF-to-VSF were calculated. Standard iron laboratory parameters were collected at least one month prior to MRI. Pearson correlation coefficient was used for correlation analysis. RESULTS: The mean age of participants was 53.9 ± 19.6 years. IMF positively correlated with R2* values in the ROI (p = 0.005, rs = 0.382) and entire liver (p = 0.016, rs = 0.332). Conversely, VSF negatively correlated with R2* values from the ROI (p = < 0.001, rs = - 0.488) and entire liver (p = < 0.001, rs = - 0.459). Positive correlations were also found between IMF-to-VSF and R2* of the ROI (p = 0.003, rs = 0.400) and whole liver (p = 0.008, rs = 0.364). Ferritin levels positively correlated with R2* values calculated from ROI (p = 0.002, rs = 0.417) and whole liver volume (p = 0.004, rs = 0.397). A positive correlation was noted between PDFF of the entire liver and TF (p = 0.024, rs = 0.313). CONCLUSION: The percentage of Intermuscular and visceral adipose tissues correlates with the severity of liver iron overload in hemochromatosis patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Hemochromatosis - diagnostic imaging
- Retrospective Studies - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Magnetic Resonance Imaging - methods
- Middle Aged - administration & dosage
- Iron Overload - diagnostic imaging
- Adult - administration & dosage
- Adipose Tissue - diagnostic imaging
- Severity of Illness Index - administration & dosage
- Liver - diagnostic imaging
- Aged - administration & dosage
- Body Composition - administration & dosage
- Find related publications in this database (Keywords)
- Hemochromatosis
- Iron metabolism disorders
- Body fat distribution
- Magnetic resonance imaging