Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Golomb, RC; Tittel, SR; Welters, A; Karges, W; Meyhöfer, S; Hummel, M; Mader, JK; Kämmer, JC; Schloot, NC; Holl, RW.
Increased cardiovascular risk in people with LADA in comparison to type 1 diabetes and type 2 diabetes: Findings from the DPV registry in Germany and Austria.
Diabetes Obes Metab. 2025; 27(2):563-573
Doi: 10.1111/dom.16048
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Mader Julia
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- INTRODUCTION: We aimed to characterise and compare individuals diagnosed with type 1 diabetes (T1D), latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D), in a real-world setting. METHODS: Anthropometric and clinical data from 36 959 people with diabetes diagnosed at age 30-70 years enrolled in the prospective diabetes patients follow-up (DPV) registry from 1995 to 2022 were analysed cross-sectionally at diagnosis and follow-up (≥6 months after diagnosis). LADA was defined as clinical diagnosis of T2D, positivity of ≥1 islet autoantibody and an insulin-free interval of ≥6 months upon diabetes diagnosis. RESULTS: At diagnosis, age, body mass index, waist circumference, C-peptide and HbA1c in people with LADA (n = 747) fell in between individuals with T1D (n = 940) and T2D (n = 35 272) (all p-values < 0.01). At follow-up, after adjusting for age, sex and diabetes duration, the prevalence of dyslipidemia and hypertension was the highest in people with LADA (90.6%, 77.7%) compared to people with T2D (81.8%, 60.4%) and T1D (75.7%, 39.7%) (p < 0.01). The prevalence of diabetic kidney disease (DKD) was higher in LADA (44.2%), than in T1D (19.9%) (p < 0.01). The prevalence of peripheral neuropathy was higher in individuals with LADA (55.1%) than in T2D (43.9%) and T1D (42.1%) (p < 0.05). Coverage of treatment for hypertension and dyslipidemia were 22.4% and 15.0% in T1D, 63.0% and 36.6% in LADA and 29.4% and 18.2% in T2D. CONCLUSION: People with LADA had a higher prevalence of cardiovascular risk factors (dyslipidemia, hypertension) and cardiovascular complications (DKD and peripheral neuropathy), suggesting that people with LADA are at need for improved recognition and care.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Middle Aged - administration & dosage
- Diabetes Mellitus, Type 2 - epidemiology, complications, blood
- Male - administration & dosage
- Female - administration & dosage
- Diabetes Mellitus, Type 1 - complications, epidemiology, blood
- Registries - administration & dosage
- Germany - epidemiology
- Adult - administration & dosage
- Austria - epidemiology
- Aged - administration & dosage
- Cardiovascular Diseases - epidemiology, etiology
- Cross-Sectional Studies - administration & dosage
- Latent Autoimmune Diabetes in Adults - epidemiology, complications
- Heart Disease Risk Factors - administration & dosage
- Prevalence - administration & dosage
- Dyslipidemias - epidemiology, complications
- Prospective Studies - administration & dosage
- Hypertension - epidemiology, complications
- Follow-Up Studies - administration & dosage
- Diabetic Nephropathies - epidemiology
- Find related publications in this database (Keywords)
- cardiovascular disease
- database research
- dyslipidaemia
- real-world evidence
- type 1 diabetes
- type 2 diabetes