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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Seys, SF; Schneider, S; de, Kinderen, J; Reitsma, S; Cavaliere, C; Tomazic, PV; Morgenstern, C; Mortuaire, G; Wagenmann, M; Bettio, G; Ciofalo, A; Diamant, Z; Eckl-Dorna, J; Fokkens, WJ; Holzmeister, C; Mariën, G; Masieri, S; Otten, J; Scheckenbach, K; Tu, A; Bachert, C, , CHRINOSOR, consortium.
Real-world effectiveness of dupilumab in a European cohort of chronic rhinosinusitis with nasal polyps (CHRINOSOR).
J Allergy Clin Immunol. 2025; 155(2):451-460
Doi: 10.1016/j.jaci.2024.10.016
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Holzmeister Clemens
- Tomazic Peter Valentin
- Study Group Members Med Uni Graz:
- Andrianakis Alexandros
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- Abstract:
- BACKGROUND: Pivotal studies with dupilumab demonstrated clinically relevant improvements in nasal polyp score, symptom score, and quality-of-life score in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). OBJECTIVE: We evaluated the effectiveness of dupilumab in a large-scale CRSwNP cohort from 6 European tertiary-care centers. METHODOLOGY: Nasal polyp score, Sinonasal Outcome Test 22 score, visual analog scale for total sinus symptoms, loss of smell, and nasal blockage, and Asthma Control Test (ACT) score were collected from hospital records and assessed at baseline and again at 24 and 52 weeks' treatment with dupilumab in CRSwNP patients. Treatment effectiveness was evaluated in relation to demographic and lifestyle factors, sinus surgery history, presence of comorbidities, and blood eosinophil counts (BEC). Treatment response was evaluated according to European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) 2021 criteria. RESULTS: All patient outcomes improved at 24 and 52 weeks' treatment compared to baseline. Dupilumab showed effectiveness independent of age, sex, body mass index, smoking status, prior sinus surgery, presence of asthma, nonsteroidal anti-inflammatory drug-exacerbated respiratory disease, allergy, or baseline BEC. A total of 92.5% and 94.4% showed an improvement in at least 1 EUFOREA criterion at 24 and 52 weeks, respectively; 54.4% and 68.2% met all 4 of the more stringent EUFOREA criteria at 24 and 52 weeks, respectively. CONCLUSIONS: Real-world evaluation of dupilumab effectiveness demonstrates a robust and sustained response in at least two thirds of patients at 52 weeks' treatment. Favorable treatment response was independent of the number of sinus surgery procedures, major comorbidities, or baseline systemic levels of type 2 inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Nasal Polyps - drug therapy, immunology
- Sinusitis - drug therapy
- Antibodies, Monoclonal, Humanized - therapeutic use
- Male - administration & dosage
- Female - administration & dosage
- Rhinitis - drug therapy
- Chronic Disease - administration & dosage
- Middle Aged - administration & dosage
- Adult - administration & dosage
- Europe - administration & dosage
- Treatment Outcome - administration & dosage
- Cohort Studies - administration & dosage
- Aged - administration & dosage
- Quality of Life - administration & dosage
- Rhinosinusitis - administration & dosage
- Find related publications in this database (Keywords)
- Chronic rhinosinusitis
- nasal polyps
- biologic therapy
- real-world evidence
- asthma
- sinus surgery
- effectiveness
- dupilumab