Medizinische Universität Graz - Research portal
Selected Publication:
Omerovic, S.
Reproduzierbarkeit der T Wellen Alternans Messung bei Patienten mit ischämischer Kardiomyopathie
[ Diplomarbeit/Master Thesis ] Graz Medical University; 2009. pp.65.
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- Authors Med Uni Graz:
- Advisor:
- Heinzel Frank
- Lercher Peter
- Pieske Burkert Mathias
- Altmetrics:
- Abstract:
- Introduction: Patients with ischemic cardiomyopathy have a high risk to die suddenly. There are several risk markers used in the clinical routine to predict the risk of sudden cardiac death. At present, however, there is not a single risk marker that exactly can predict the risk of dying suddenly. The T-wave Alternans is another non invasive risk factor that was evaluated in several studies. The reproducibility is crucial using a new clinical method. At present there are only studies dealing with short term reproducibility of 4 hours, data about long term reproducibility are still limited. Aim: The aim of this study was to evaluate the 24 hour reproducibility of the two currently available Microvolt T-wave Alternans (MTWA) methods (frequency domain method and time domain analysis) in patients with ischemic cardiomyopathy and severely reduced left ventricular ejection fraction. Methods: Patients with an implanted cardioverter-defibrillator (primary and secondary prevention) were included in this study. After informed consent patients were randomized to one of the two MTWA methods (Cambridge Heart System, GE Healthcare System). An exercise treadmill test was performed on day 1 and day 2 according to the TWA protocol. Results: In this prospective clinical study a total of 19 patients were included. The mean age was 63 7 years; the mean ejection fraction was 25 5 %. 10 patients were evaluated using the Time Domain Analysis (GE Healthcare). There was no difference at day 1 and day 2 (39,6 13,8 V versus 39,1 13,2 V ). TWA measurements of the Cambridge Heart system revealed the same result (day 1 1,9 1,6 V; day 2 1,9 1,4 V). Conclusion: In our study we could demonstrate an exact day to day reproducibility of both TWA systems. Therefore it could be possible in the future to perform only a single TWA measurement for evaluating the risk of sudden cardiac death.