Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kussegg, NC.
Radiogene Optikusneuropathie: Mögliche Komplikation bei radiochirurgischen Behandlungen an der zentralen Schädelbasis. eine Dosis-Wirkungsbeziehungsstudie.
[ Diplomarbeit/Master Thesis ] Graz Medical University; 2008. pp.124.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Leber Klaus
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- Abstract:
- Abstract As stereotactic radiosurgery has become a popular adjuvant treatment modality for cerebral tumors, yearly 250 patients are treated with gamma knife radiosur-gery in Graz. In 10 % of these cases the main target is the central skull base. For the proximity of tumors in this region to delicate structures, like the visual appara-tus, special care during dose planning is demanded to find a compromise be-tween achieving an optimal treatment dose and avoiding these structures from a significant radiation dose. As stereotactic procedures have high precision, structures next to the tumour can be well protected against radiation by sharp decline of dose. Thereby radiation-induced neuropathy (optic nerve, optic chiasm, optic tract) is a rare complication of Gamma Knife treatment. Undesirable ocular side effects of therapeutic radiation can lead to serious inter-ferences and to blindness, eventually. Knowledge of the radiation dose-response characteristics is essential for planning decisions. Even though there are some publications about the correlation between radiation dose and occurrence of ra-diation-induced neuropathy there has not been found a tolerance dose-level for the critical structures. This degree dissertation is to find a limit of radiation dose above which there have to be reckon with an increasing of radiation-induced neuropathy by analyz-ing information in a retrospective study.