Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gapp, M.
Extra-abdominal Desmoid Tumors: Clinical, Pathological, and Radiological Aspects in Correlation with Therapeutic Options.
[ Dissertation ] Karl-Franzens-Universität Graz; 2003. pp.67.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Welkerling Heike
- Windhager Reinhard
- Altmetrics:
- Abstract:
- Desmoid tumors originate from connective tissue and can occur everywhere in the body but show different behaviour at different sites. They do not metastasize but tend to infiltrate surrounding structures and towards local recurrence. Although these lesions are characterized as benign, this behaviour puts them in between benign and malign. Etiology and risk factors are not known although certain subtypes may be associated with pregnancy or previous trauma at the site of the late tumor. The mainstay of treatment of desmoid tumors is surgery but common treatment modalities also include drug therapy, radiation therapy and wait and see strategy. Problems of treatment are unsatisfying response rates to radiation and drug therapy and high rates of local recurrence after surgery. Magnetic resonance imaging is the modality of choice for tumor staging, initially and durgin follow up. Our goal is to establish a scheme for adjuvant treatment of extra abdominal desmid tumors based on immunohistochemical findings. An immunohistochemical examination of 84 samples of desmoid tumors including primary and recurrent lesion was done for estrogen receptor, progesterone receptor, androgen receptor, cathespin D protein, Ki 67 protein, human epithelial growth factor receptor 2 (HER2 protein), and somatostatin receptor. This study is among the ones with the biggest numbers of desmoid tumor specimens being examined and the first one to systematically examine androgen receptor, cathepsin D, Ki 67, HER2 protein. Somatostatin receptor was found in few androgen receptor and HER2 protein. Somatostatin receptor was found in few cases of extraabdominal and one intra-abdominal desmoid tumor. Ki 67 was found in 25-75% of the specimens varying for the different types of desmoid tumors. Immunohistochemical analysis of desmoid tumor cells should become the basis for improving todays options of drug therapy. Because extra-abdominal desmoid tumors are rare most studies describe only small numbers of cases and therefore optimal adjuvant treatment of this disease is largely uncertain. This study was done between December 2001 and August 2003 at the Department of Orthopedic Surgery, Karl-Franzens-University Graz, Austria, in cooperation with the Institute of Pathology, Karl-Franzens-University, Graz, Austria. It is part of the project Immunohistochemical Analysis of Extra-abdominal Desmoid Tumors that ist sponsored by the Styrian Cancer Aid (Steirische Krebshilfe, Graz, Austria), project number 05/2001, led by Univ. Ass. Dr. Andreas Leithner.