Medizinische Universität Graz - Research portal
Selected Publication:
Allmer, N.
Carcinosarcoma of the parotid gland. A clinic-pathological study with special emphasis on immunohistochemical investigations for myoepithelial markers and review of the literature.
[ Diplomarbeit/Master Thesis ] Graz Medical University; 2008.
- Authors Med Uni Graz:
- Advisor:
- Beham Alfred
- Altmetrics:
- Abstract:
- Carcinosarcoma of salivary glands are rare tumours of which at present 82 caes have been published in the literature. These cases were reviewed retrospectively with regard to clinicopathological features and compared with 3 new own cases. The tumours reported in the literature mostly occurred in patients of the 7th decade (mean 59,3 years, median 64 years9 with a slight male preponderance. The parotid gland was concerned in 64,2%, followed by the submandibular gland (19,8%) and others. About 50% of the patients died within 5 years after diagnosis thus indicating a very poor prognosis. Pathohistologically, the lesions were typically composed of both a carcinomatous and sarcomatous component, which showed histologically an adenocarcinoma NOS, ductal carcinoma, undifferentiated carcinoma, chondrosarcoma, sarcoma NOS and osteosarcoma as the most frequent types. In 27 cases remnants of a pre-existing pleomorphic adenoma could be demonstrated. Ultrastructural, immunohistochemical and genetic examinations of some cases suggested a common myoepithelial origin of both tumour components. The three own cases concerned 1 female and 2 male patients aged 45,39 and 63 years. lThe tumours were exclusively located in left parotid gland and showed diameters between 3 and 5.5 cm. Histologically, case 1 corresponded to an adenocarcinoma NOS, myoeptihelial carcinoma, myoepithelial carcinoma and chondrosarcoma, and case 3 to a salivary duct carcinoma, undifferentiated carcinoma and chondrosarcoma, osteosarcoma and fibrosarcoma. In all 3 cases residues of a pleomorphic adenoma were present. Immunohistochmeical examinations for myoepithelial markers including some markers used for the first time in characterizing salivary gland carcinosarcomas (p63, CD29, CD10) showed a reactivity of both carcinoma and sarcomas (p63, CD 29, CD 10) showed a reactivity of both carcinoma and sarcoma cells. These results strongly support and confirm the theory of a myoeptihelial origin of salivary gland carcinosarcomas as proposed by previous studies.