Medizinische Universität Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

Mattweber, M.
EEG-derived Bispectral Index (BIS) for depth of anesthesia monitoring : effect of neuromuscular blockade on the BIS-A-2000 and the BIS-XP
[ Dissertation ] Graz Medical University; 2004. pp.77.

 

Authors Med Uni Graz:
Advisor:
Metzler Helfried
Altmetrics:

Abstract:
Facial electromyographic activity and neuromuscular block could influence bispectral index (BIS) depth of anaesthesia monitoring. The purpose of our study was to examine, in 30 patients undergoing general surgical procedures, the effect of different stages of neuromuscular block on BIS monitoring and to compare the conventional A-2000 BIS TM to the new BIS-XP TM system. At deep surgical anaesthesia of BIS of about 40, under propofol 3,61 g/ml target controlled infusion and 0,15-0,3 g kg-1 min-1 remifentanil infusion, mivacurium 0,15 mg/kg was administered. The onset of neuromuscular block triggered a brief transient odd divergence in response manifesting as BIS increase from 43 +/- 4 to 49 +/- 7 (p=0,007) and BIS-XP decline from 41 +/- 3 to 35 +/- 3 (p=0,003) at 1 +/- 0,2 min and 1,4 +/- 0,5 min. After 2,5 +/- min after mivacurium administration, both monitors returned to baseline values of 43 +/- 5 and 40 +/- 4 respectively. Following that, BIS and BIS-XP did not significantly change during complete neuromuscular block or during various levels of neuromuscular recovery. At all phases, BIS-XP was significantly lower than BIS. Our study indicated that during deep surgical levels of propofol remifentanil anaesthesia, except for a brief transient odd divergence between BIS and BIS-XP artefacts in response to onset of neuromuscular block, BIS monitoring was not sensitive to the presence of absence of neuromuscular blockade. The displays values of the BIS differed from the BIS-XP, as the BIS-XP was constantly lower than the BIS. The difference are still unacceptably wide to allow values given by the two monitors to be used interchangeably for individual patients.

© Med Uni GrazImprint