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Gewählte Publikation:

Markert, E.
Cell proliferation analysis in sarcoidosis lavage cells
[ Dissertation ] University of Graz; 2003. pp.42.

 

Autor*innen der Med Uni Graz:

Betreuer*innen:

Popper Helmuth

Smolle-Juettner Freyja-Maria

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Abstract:

Until today the causes and triggers of sarcoidisis are not identified. Subject of this study was to analyse genes of the proliferation-pathway via PI3K and Akt. This investigation was bases on the consideration that enhanced proliferation might be responsible for the presence of immunocompetent cells in sarcoidosis. Using real-time PCR, we were able to find out that genes of this pathway are not overexpressed, except of one catalytic subunit of PI3K. Therefore we assumed that there is a proliferation stimulus primary aiming onto another pathway. Additionally, we found evidence that apoptosis is inhibited.

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