Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mogg, V.
First trimester biomarkers for gestational diabetes
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 142
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Hiden Ursula
- Stern Christina
- Altmetrics:
- Abstract:
- The aim of this review is to identify potential early biomarkers for gestational diabetes mellitus (GDM). A comprehensive literature search was conducted in PubMed using the key words: GDM/gestational diabetes – biomarker/screening – early pregnancy/first trimester. This search yielded a wide range of studies, which were thoroughly analysed. After excluding duplicate studies and those that did not meet the inclusion criteria or could not be categorized, a total of 182 studies from around the world were included in the final analysis. These studies explored the association between various biomarkers and screening methods with GDM. The results indicated detectable differences in the first trimester between women who later developed GDM and those who did not. Among the promising biomarkers identified are various adipokines, ferritin, ultrasound measurements, and microbial features. Given the diversity of potential early risk predictors, it can be concluded that the most effective approach for the early detection of GDM may involve a combination of the most promising biomarkers.