Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lyssy, F.
The role of platelet-derived factors on extravillous trophoblasts
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Gauster Martin
- Schlagenhauf Axel
- Altmetrics:
- Abstract:
- During human placentation extravillous trophoblasts (EVTs) migrate into the maternal endometrium and form plugs in uterine spiral arteries to prevent maternal blood from entering the intervillous space (IVS). By mid-first trimester, these plugs loosen and form capillary-sized channels. Given their small size, platelets might be the first maternal blood cells to enter the IVS. Activated platelets have been found within these intercellular gaps, supporting the hypothesis that activation of maternal platelets affects surrounding trophoblasts. One of my studies investigated sphingosine 1 phosphate receptors S1PR1–S1PR3 in the placenta across gestation. S1PR2 was dominantly expressed in the first trimester but decreased towards term, while S1PR1 and S1PR3 increased. S1PR1 was mainly in endothelial cells, whereas S1PR2 and S1PR3 were in villous trophoblasts. BeWo cell experiments showed that platelet-derived factors significantly downregulated S1PR2, suggesting a link between increasing platelet presence and S1PR2 decline in the placenta over gestation.