Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Freudenthal-Siefkes, J.
Immune Response to ZX00 Implants in Healthy and Osteoporotic Rats
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 63
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Sommer Nicole
- Altmetrics:
- Abstract:
- Background: In the EU, one out of three women and one out of five men will experience an osteoporotic fracture over their course of life. In 2019, 4.28 million osteoporotic-associated fragility fractures were reported. Due to increased life expectancy, the number of fragility fractures is estimated to reach 5.28 million by 2034. Osteosynthesis of osteoporotic bone presents a particular challenge due to alterations in the mechanical, immunological, and regenerative properties of the bone. Therefore, the requirements of implant materials changed to gain a better osseointegration, osteoconductivity, and osteoinductivity. Biodegradable magnesium (Mg)-based implants, such as ZX00, showed promising results in animal studies and in a first in-men study. Recently, results in osteoporotic rats revealed accelerated degradation of ZX00 compared to healthy rats. Hence, we aimed to investigate the systemic osteoimmunomodulatory changes during osteoporosis development and osteogenic properties of ZX00 in a rat model. Therefore, we assessed in the first phase of the study the systemic immunomodulatory response and the bone morphologic changes to the onset of osteoporosis and in the second phase the local morphogenic and systemic immune response to ZX00 in osteoporotic and healthy conditions.