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Woltsche, N.
IMMUNE RESPONSE AND CONJUNCTIVAL BACTERIAL FLORA IN PATIENTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS TREATED WITH DUPILUMAB
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 84 [OPEN ACCESS]
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Authors Med Uni Graz:
Advisor:: Horwath-Winter Jutta; Patra Vijaykumar; Wolf Peter
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Abstract:: Introduction: Dupilumab-associated ocular surface disease (DAOSD) is a frequent atopic dermatitis specific side effect of this otherwise well tolerated monoclonal antibody therapy. The underlying pathogenesis has not been clearly understood yet. Material and Methods: In this prospective single-center study, adult patients with moderate to severe atopic dermatitis scheduled for 16 weeks Dupilumab treatment were enrolled, and a slit-lamp examination, a whole-body dermatological examination, conjunctival smears for haematoxylin and eosin staining, conjunctival swabs for microbiome analyses and blood sampling for serum cytokine profiling were conducted at least at three visits - at baseline before Dupilumab initiation, at one month after treatment start and at the end of Dupilumab treatment after four months.