Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Oliinyk, B.
Comparison of Machine Perfusion Solutions in Liver, Kidney and Pancreas Transplantation: a Comprehensive Review
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 138
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Leber Bettina
- Stiegler Philipp
- Altmetrics:
- Abstract:
- In recent years, machine perfusion has gained attention as a promising alternative to cold storage during graft storage in transplantation, offering dynamic preservation by continuously perfusing organs to mimic physiological conditions. The primary perfusion modalities—hypothermic machine perfusion (HMP), subnormothermic machine perfusion (SNMP), and normothermic machine perfusion (NMP)—present opportunities to enhance preservation quality, minimize ischemic injury, and expand the donor organ pool by making marginal organs viable for transplantation. Despite these advancements, the choice of perfusion solution remains a critical factor that influences the success of organ preservation and transplantation outcomes. The composition and properties of perfusion solutions can impact cellular metabolism, tissue integrity, and overall organ function. Therefore, it is essential to explore and evaluate different perfusion solutions systematically to determine their efficacy across various perfusion modalities. Standardizing the use of the most suitable perfusion solutions could lead to improved organ viability, better transplantation outcomes, and increased availability of donor organs.