Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Neururer, M.
The cGAS-STING pathway drives inflammation in Usual Interstitial Pneumonia, phagocytosis could prevent inflammation but is inhibited by the don’t eat me signal CD47
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Popper Helmuth
- Altmetrics:
- Abstract:
- Background: Usual Interstitial Pneumonia (UIP) a fibrosing pneumonia is associated with idiopathic pulmonary fibrosis, chronic autoimmune disease (AID), or hypersensitivity pneumonia. Oxygen radicals, due to tobacco smoke, can damage DNA and might upregulate PARP1. Cytosolic DNA from dying pneumocytes activate cyto- solic GMP-AMP-synthase–stimulator of interferon genes (cGAS-STING) pathway and TREX1. Prolonged inflam- mation induces senescence, which might be inhibited by phagocytosis, eliminating nuclear debris. We aimed to evaluate activation of cGAS-STING-TREX1 pathway in UIP, and if phagocytosis and anti-phagocytosis might counteract inflammation.