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Gewählte Publikation:

Reinprecht, C.
Eukaryotic initiation factor 4E as a potential therapeutic target in psoriasis
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 63 [OPEN ACCESS]
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Autor*innen der Med Uni Graz:

Betreuer*innen:

Golob-Schwarzl Nicole

Wolf Peter

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Abstract:

Background: Approximately 3 % of the world's population suffer from psoriasis. It is known that eukaryotic translation initiation factor 4E (eIF4E) plays a crucial role in important cellular processes such as proliferation, apoptosis and differentiation. A previous study by our group showed overexpression of eukaryotic translation initiation factor 4E (eIF4E) in psoriatic skin lesions. Here we reported that inhibition of eIF4E by a novel eIf4E inhibitor ("compound no. 31") leads to a reduction of eIF4E and its interaction partner’s eIF4A and eIF4G in vitro.

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