Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Prinz, F.
Cellular and molecular mechanisms of non-coding RNAs in gastrointestinal malignancies
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 113
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Kargl Julia
- Pichler Martin
- Rinner Beate
- Altmetrics:
- Abstract:
- Biliary tract cancers (BTC) stand out among gastrointestinal malignancies for their high mortality rates and limited treatment options, emphasizing the need for new molecular targets to guide the development of therapeutic strategies. In an effort to uncover novel regulatory networks involving non-coding RNAs, we focused on the miR-200 family, with its impact on the epithelial-mesenchymal transition (EMT) and its more recently described role in immune evasion mechanisms like immune checkpoint (IC) expression. We aimed to investigate the relationship between EMT and immune evasion in BTC, with the miR-200 family as potential regulatory interface.