Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kleinherr, J.
Visualization of tumor-associated microbiota in lung cancer 16S rRNA FISH analysis in tumor tissue
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Gorkiewicz Gregor
- Zacharias Martin
- Altmetrics:
- Abstract:
- Background/Introduction: Lung cancer is and remains a very serious diagnosis and it is not surprising that the large field of microbiome research, which has been booming for around 20 years, has also focused on the topic of lungs and lung cancer. Following the successful detection and rough description of a specific respiratory microbiome not too long ago, recent research results describe a local microbial flora in solid tumors, including lung tumors. While an alteration of the local microbiome has been demonstrated for chronic inflammatory lung diseases, the description of the specific tumor microbiome in lung tumors is not yet very detailed. However, an association between microbes and lung tumors has already been clearly demonstrated. But particularly information on the spatial allocation of microbes in tumor tissue and the possible conclusions on carcinogenesis and pathophysiology in the context of lung tumors are still largely lacking.