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Selected Publication:

Katz, L.
Role of the autophagy inhibiting molecule “Rubicon” in the pathogenesis of cholestatic liver injury in animal models
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.

Authors Med Uni Graz:
Advisor:: Gulden Lukas Michael; Wagner Martin
Altmetrics:
Abstract:: Backgrounds & aims: Autophagy is a vital cell process for nutrient provision and waste removal. It is mainly regulated by the mTOR pathways. However, in the liver autophagy can be influenced by bile acids and in cholestatic conditions. Our lab discovered that cholestasis impairs autophagy via bile acid activated FXR, which upregulates "Rubicon", an autophagy inhibitor. We hypothesized that inhibiting "Rubicon" could be a potential rescue mechanism for hepatocytes in cholestatic liver conditions.