Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Geles, A.
The influence of various factors on the survival rate of mucinous and non-mucinous lung adenocarcinoma
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 92
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Popper Helmuth
- Smolle-Juettner Freyja-Maria
- Swatek Paul
- Altmetrics:
- Abstract:
- Lung Adenocarcinoma is the most common type of lung cancer and one of the most dangerous diseases of humankind, which can lead to death if not treated. It accounts for approximately 40-50% of all lung cancers, representing 50-60% of all NSCLC cases. Within this spectrum, approximately one-third differentiate along a mucinous pathway. It has been claimed, that mucinous adenocarcinomas behave worse than their non-mucinous counterpart. Invasive mucinous, colloid, and enteric adenocarcinomas are variants of adenocarcinomas. Between 2002 and 2012 we identified 335 surgically resected cases of mucinous and non-mucinous adenocarcinomas. The aim of the study is to compare the overall survival as well as the progression-free survival of mucinous versus non-mucinous adenocarcinomas of the lung. We also investigated 76 mucinous adenocarcinomas, including colloid variants, for their predominant and secondary patterns, their different form of mucin storage and release, their expression of cytokeratins 7 and 20, TTF1 and CDX2, and MUC1, 2 and 5AC proteins, their expression of p14, and p16 proteins, their possible rearrangements for EML4ALK and ROS1, as well as their KRAS mutational status and correlated this with survival. For comparison 259 non-mucinous adenocarcinomas were selected.