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Gewählte Publikation:

Cichocki, F.
CHARACTERISATION OF CARDIAC FUNCTION AND STRUCTURE IN AN ATHEROSCLEROSIS PRONE MOUSE MODEL OF OBESITY AND TYPE 2 DIABETES
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 59 [OPEN ACCESS]
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Autor*innen der Med Uni Graz:

Betreuer*innen:

Bugger Heiko Matthias

Byrne Nikole

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Abstract:

Obesity and Type 2 diabetes mellitus (T2DM) increase the risk for heart failure (HF), including diastolic dysfunction. While animal models of obesity and T2DM used for mechanistic research display diastolic dysfunction, these models usually lack development of atherosclerosis unless an atherosclerosis predisposing mutation has been included. Thus, these animal models do not allow to estimate the additional contribution of atherosclerosis and vascular dysfunction which however commonly develop in humans with T2DM. Thus, the aim of the current study was to investigate the effects of obesity and T2DM on cardiac function and structure in a mouse model that also develops atherosclerosis.

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