Medizinische Universität Graz - Research portal
Selected Publication:
Howischer, T.
Movement disorders, clinical progression and causes of death in anti-IgLON5 Disease - Case report and review of the literature
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.
- Authors Med Uni Graz:
- Advisor:
- Gattermeyer-Kell Lukas
- Schwingenschuh Petra
- Altmetrics:
- Abstract:
- Background: Anti-IgLON5 disease is a neurological disorder characterised by both autoimmune and neurodegenerative mechanisms. The first cases of the disease were described in 2014, which is why there is not yet much literature available. The high mortality rate makes the analysis of causes of death particularly relevant. Methods: The study is divided into two parts. The first part consists of a systematic literature research focusing on causes of death from the disease. In the second part, a case report of a patient with anti-IgLON5 disease is presented. Results: The most common cause of death is “sudden death” with a percentage of 40 %. This is followed by “death due to complications”, which consists mainly of aspiration pneumonia, but also includes trauma from falls. Other causes are respiratory, cardiac and unknown causes. The patient in the case report demonstrates a cardiac cause of death. Discussion: The strikingly frequent occurrence of “sudden death” raises the question of why so many patients experience it and what underlying causes exist. The assumption is that unrecognised cardiac causes are often responsible for “sudden death”. The IgLON5 patient presented here who was additionally diagnosed with cardiac amyloidosis is also an example of cardiac sudden death.