Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Unterberger, CL.
Deciphering the role of PKM1 and PKM2 in human dendritic cell and Langerhans cell development and functionality.
[ Diplomarbeit/Master Thesis (FH) ] FH Campus Wien; 2024. pp.77.
FullText
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Angiari Stefano
- Altmetrics:
- Abstract:
- Studies in the field of immunometabolism have demonstrated that inflammatory responses are regulated via the modulation of the intracellular metabolic profile of immune cells. Accordingly, targeting immune cell metabolism represents a new strategy for the treatment of inflammation. Pyruvate kinase (PK) is the enzyme catalysing the final step in glycolysis, and immune cells preferentially express the PK isoenzymes M1 (PKM1) and M2 (PKM2). PKM2 can be expressed in the cell in a tetrameric form or in a monomeric/dimeric one. In this latter form PKM2 is able to translocate into the nucleus, where it performs non-canonical moonlighting functions such as protein kinase activity and regulation of gene transcription. Some of these moonlighting functions are reported in immune cells control their activation and effector functions. However, if PKM2 moonlighting also has a role in the development and differentiation of immune cells from uncommitted precursors is currently unknown.