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Gewählte Publikation:

Rathofer, I.
The Use of Tranexamic Acid in Traumatic Brain Injury
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.

 

Autor*innen der Med Uni Graz:

Betreuer*innen:

Farzi Aitak

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Abstract:

Introduction: Since Tranexamic Acid (TXA) was first synthesised in the 1960s, it has become increasingly relevant in the treatment of medical conditions that are associated with substantial blood loss. In critical care medicine this is particularly relevant in the context of trauma. Blood loss is the most common cause of early death in trauma patients, while traumatic brain injury (TBI) is the most frequent origin of delayed death and morbidity due to injuries to brain and its encasing structures. Current studies have set out to determine, whether the application of antifibrinolytic drugs such as TXA, which inhibits fibrinolysis via reducing the activation of plasmin, can have beneficial influences on mortality rates and neurologic function of patients after TBI.

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