Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stimmeder, S.
Graft Optimization during Ex Vivo Organ Perfusion: the Potential of Genetic Modulation
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Leber Bettina
- Stiegler Philipp
- Altmetrics:
- Abstract:
- Dynamic preservation methods such as normothermic, sub-normothermic and hypothermic machine perfusion circuits have emerged as viable alternatives to conventional static cold storage (SCS). These organ perfusion technologies not only serve as preservation methods, but also enable organ assessment, reconditioning, and repair prior to transplantation. Gene therapy is a novel strategy with the potential to transform the field of graft optimization and treatment. Thereby specific pathways involved in the transplantation process can be targeted and modified. This review aims to provide an overview of gene delivery methods during ex vivo machine perfusion of kidney and liver grafts. Recent literature on state-of-the-art gene therapy approaches during ex situ organ preservation, especially with respect to ischemia-reperfusion injury (IRI), as well as acute and chronic graft rejection, has been analyzed. Additionally, potential challenges that could affect further refinement of this therapeutic modality are outlined.