Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wuenscher, S.
Do Sex-Specific Factors Influence the Surgical Treatment of Facial Skin Cancer?
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Cambiaso Daniel Janos
- Spendel Stephan
- Altmetrics:
- Abstract:
- Background and Objectives: Facial skin cancer, the most common malign neoplasm in the human population, is prone to incomplete excision due to the sophisticated anatomy and the aesthetic importance of the face. Adjuvant therapy modalities following incomplete cancer excision are associated with increased morbidity and healthcare cost, resulting in secondary surgery. Given its prevalence and the delicate nature of facial tissues, facial skin cancer surgery requires meticulous attention to ensure optimal outcomes. We sought to investigate to what extent sex-specific factors affect the re-resection rate in facial skin cancer. Patients and Methods: In this retrospective study, patients (>18 years) undergoing surgical excision of a facial skin cancer were enrolled. Of each patient demographic data, cancer location, the surgical team, primary and secondary surgeries were analyzed. Results: A total of 469 patients underwent 819 surgeries. The mean age was 69±15 years. No significant association between sex-specific factors (surgeon’s sex (OR:1.09, 95%CI:0.76–1.56) or patient’s sex (OR:0.85, 95%CI:0.62–1.17), surgeon-patient sex concordance and discordance) and the likelihood of secondary surgery was found. However, healing by secondary intention (OR:4.28; 95%CI:1.94-9.45) and cancer location showed an increased re-resection rate. Conclusions: In conclusion, facial skin cancer surgery is a generally safe method, and sex- specific factors alone did not significantly impact the re-resection rate. Nonetheless, other factors such as healing by secondary intention and cancer location influenced the likelihood of re-resection. Future multicenter studies should further investigate this phenomenon.