Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kulnik, SK.
Role of B. pseudomallei BopA in primary human macrophage cell death.
[ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2021. pp.47.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Wagner-Lichtenegger Sabine
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- Abstract:
- Burkholderia pseudomallei is a gram-negative pathogen, which is mostly endemic in southeast Asia and northern Australia. It is the causative agent of melioidosis, an infectious disease affecting humans and animals. The disease causes a wide variety of symptoms and has a mortality rate similar to measles, with as much as 89,000 deaths per year. B. pseudomallei spreads intracellularly and can invade phagocytic and non-phagocytic cells alike. It possesses a Type 3 Secretion System-3 (T3SS-3), which is essential for successful invasion of the host cell and spread. It delivers effector proteins into the host cytosol, which are able to subvert the immune response. Therefore, investigation of the interactions between T3SS-3 proteins and the host are relevant for future treatment options. One of the effector proteins secreted by B. pseudomallei is BopA. The aim of this study was to investigate different pathogen-induced cell death mechanisms in primary human macrophages. Specifically, the role BopA plays during these mechanisms was analysed.