Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Waltl, K.
The effect of the polyamine spermidine on heart function assessed by echocardiography
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 78
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Kolesnik Ewald
- von Lewinski Dirk
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- Abstract:
- Background and Aim: Arterial hypertension is the main risk factor for cardiovascular diseases (CVDs) and deaths with increasing incidence. In an animal study, it could already be proven that the supplementation with the polyamine spermidine led to lower blood pressure levels in mice. This thesis aims to give further insights into the possible cardioprotective effects of spermidine on heart function in patients with hypertension disease assessed by both conventional echocardiographic and strain parameters. Material and Methods: This work was based on retrospective data analysis of echocardiographic loops of 20 patients with arterial hypertension from the SMARTEST trial at four points in time (weeks 0, 8, 12, and 20). The subjects received 4mg spermidine per day and a placebo for each eight weeks with a washout interval of four weeks in between in a crossover design. Standard echocardiographic and strain parameters of visit 1 and visit 4 were statistically evaluated and compared with each other to assess cardiac function. Results: The results of this study showed no significant changes in left ventricular (LV) function and volumes, right ventricular (RV) function and diameter, left atrial (LA) function and diameter, and diastolic function between visit 1 and visit 4. Regarding strain analyses, a strong positive correlation between LV Endo global longitudinal strain (GLS) and LV AutoStrain (r = 0.651) as well as a strong negative correlation between biplane left ventricular ejection fraction (LVEF) and Endo GLS (r = -0.593) were determined on visit 4. Conclusion: The administration of spermidine in hypertensive patients did not lead to any significant echocardiographic changes in volume, linear, and strain parameters. Nevertheless, this work could show the safety of oral spermidine supplementation on cardiac function in hypertensive patients evaluated by echocardiography. Further clinical research is necessary for the proof of the possible cardioprotective effects of spermidine and the understanding of the importance of GLS in hypertension disease.