Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wagner, A.
Comparison of Revision Rates and Epidemiological Data in Total Knee Arthroplasty with the ATTUNE Knee System. An analysis of clinical trials and national arthroplasty registries.
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2023. pp. 88
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Sadoghi Patrick
- Wittig Ulrike
- Altmetrics:
- Abstract:
- Background: The purpose of this study was to evaluate and compare national prosthesis registers and clinical trials data on the DePuy Synthes Attune Knee System. Emphasis was placed on epidemiologic data, revision data, and data from different surgical techniques. Methods: All national knee registries between 1999 and 2022 and all clinical studies between 2012 and 2022 were reviewed and evaluated regarding the Attune Knee System. A special interest was placed on revision data, epidemiological data, and data from different surgical techniques and design principles. Surgical techniques were divided into cruciate retaining (CR) and posterior stabilized (PS) techniques. The design principles in fixed-bearing (FB) and mobile bearing (MB). Results: 10 registries and 4 studies provided sufficient data after applying the inclusion criteria and were included in the study. The median age at implantation of an Attune knee prosthesis was 66.7 years and the mean BMI was 29.4 kg/m2. Patients were 60% female and 40% male at the time of implantation. The Swiss registry (SIRIS) shows the highest revision rates for the Attune Knee System compared to the German (EPRD), American (AAOS), Australian (AO-ANJRR), and England, Wales, and Northern Ireland (NJR) registries. A comparison of the German registry (EPRD) and the registry of England, Wales and Northern Ireland (NJR) shows that the mobile bearing design principle has an advantage over fixed bearing in terms of revision rates in the first 5 years after implantation of an Attune knee prosthesis. When usingthe fixed bearing design, there is an advantage in revision rates for the combination with the cruciate retaining technique over the posterior stabilization technique. The data regarding direct comparisons in revision rates of cruciate retaining/posterior stabilization are heterogeneous and differ within countries. Conclusion: The data regarding the Attune Knee System from the studies were mainly used for the epidemiological evaluations and the data from the national registries were used for the revision rates. Similar low revision rates were published in the registries. The epidemiologic data were also similar except the sex distribution. For the sex distribution, very heterogeneous data were published. A differentiation of several national registries into 15 construction principles (FB/MB) and surgical techniques (CR/PS) would be desirable in the future to be able to compare them better.