Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Erlacher, L.
The role of chemokine receptors in the progression of brain metastases in colon- and clear cell renal cell carcinoma
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2023. pp. 49
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Aigelsreiter Ariane
- Leoni Marlene
- Altmetrics:
- Abstract:
- Renal cell carcinoma is a epithial malignant carcinoma with increasing incidence. Patients are usually males between 50 and 69 years. The exception are younger patients who suffer from a familial form. There are no known risk factors beside the usually known Life-style ones. They metastasize mostly hematogenously, 15% of metastases are found in the brain. 20% of them also metastasize through/via the lymphatic system. The most common subtype of the renal cell carcinoma is the clear cell renal cell carcinoma (ccRCC) which is one focus of this thesis. As ccRCC, colorectal carcinoma is also a subject of this thesis. It is one of the top malignant causes of death in Europe, the incidence is increasing but depends on geographical factors. Diagnosed patients are also usually older males. There are different (genetical) pathways causing progression of colorectal cancer, the most common entity are adenocarcinomas. They most likely metastasize into lymph nodes through the lymphatic system, but also hematogenously to the liver and further. The treatments of metastases in the brain are really limited. Chemokines and their receptors most likely play an important but nearly unknown role in the process of metastasizing – it is the aim of this thesis to explore this role. The focus of this thesis is to explore the expression of different chemokines and their receptors of the primary tumors (of ccRCC and colorectal Cancer) and its brain metastases. The gained knowledge could pave the way for new treatments like targeted therapies for terminal patients. RT-qPCR was used to explore the expression of the most well characterized chemokine receptors (CCR1-10, CXCR1-7, XCR1 and CX3CR1). The result of this thesis is, that the expression of all tested Chemokine receptors (CCR4,6,8,9 and CXCR4 and 6) can be found on all primary tumors and their metastases in the brain. In renal carcinomas there is a higher expression of CCR8,6 and 9 in the metastases. In colorectal carcinomas there is a significant higher expression of CXCR6 in the metastases