Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wieser, J.
Nephrotic, what else? A retrospective kidney biopsy study
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2023. pp. 75
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Kolland Michael
- Rosenkranz Alexander
- Altmetrics:
- Abstract:
- The nephrotic syndrome is defined as the presence of proteinuria, hypalbuminaemia and oedema it is a common condition associated with primary glomerular disease or systemic diseases affecting the kidney. Goal of this study: display the epidemiology of kidney diseases causing nephrotic syndrome. Between 2007 to 2017 kidney biopsy data of 984 patients was collected at the department of nephrology at the medical university of Graz. 243 (158 male) were included (nephritic/graft excluded) is this study and split into different disease type groups according to their histologically proven disease. Further the patientgroup was divided into nephrotic and non-nephrotic patients. The following evaluation was limited to patients with nephrotic syndrome. Patient characteristics were compared, renal and nephrotic parameters such as proteinuria, serum albumin and creatinine values, distribution of renal haematuria and nephritic sediment analysed, immunological parameters at baseline explored, antihypertensive drug-therapy data and complications of biopsy data collected. Additionally, the outcome was analysed regarding the markers for chronicity, acute-kidney-injury, kidney-replacement-therapy and the disease types MCD, FSGS, MN, hypertensive nephropathy (HN), diabetic kidney disease (DKD) and amyloidosis (AL). For all the statistic calculations program IBM SPSS Statistics 28.0.1 program was used. In total 119 (49%) patients (78 male) were classified as nephrotic and 124 (51%) as non-nephrotic (80 male). For the other groups the following numbers were observed: MCD 34 (14%), FSGS 24 (9,9%), MN 53 (21,8 %), ‚HN 46 (18,9%), DKD 19 (7,8%), AL 14 (5,8%), acute kidney injury (AKI) 22 (9,1%), normal kidney parenchyma (NKP) 12 (4,9%) the remaining groups were sum up under “other”. Renal haematuria was observed: FSGS 19 (79,2%), MN 43 (81,1%), HN 29 (63,0%), DKD 17(89,5%), AL 10 (71,4%), AKI 13 (59,1%) and NKP 5 (41,7%). For MCD, which also displays the most nephrotic patients, renal haematuria 22 (64,7%) and nephritic sediment 17 (50%) was observed. Further a second peak of adult MCD patients was observed between 40 to 60 years. In this study, a relatively high percentage of the patients with nephrotic syndrome examined showed a nephritic sediment, although a uniform definition of nephritic sediment cannot be found in the literature and should be defined more precisely.