Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Glatz, U.
The effects of different doses of basal insulin on the cardiac and metabolic responses during exercise testing in people with type 1 diabetes
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2023. pp. 56
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Eckstein Max Lennart
- Moser Othmar
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- Abstract:
- Abstract Aim The aim of the thesis was to compare the effects of a regular (100%) vs. 75% dose of insulin Glargine U300 (IGlar U300) on the cardiac and metabolic markers during several spontaneous exercise sessions. Material and methods Data from 15 physically active adult participants (eight male, seven female) with T1DM in good glycemic control were obtained from a larger study. Ultraflexi-1 is a randomized single-center four period cross-over trial (IGlar U300, IDeg U100 each in the dosage 100% and 75%). In each period, six training sessions were conducted within two consecutive weeks, in which the participants performed 60 minutes of exercise on a cycle ergometer, including 54 minutes at a VO2max of around 66% (moderate intensity). For this thesis, only data regarding IGlar U300 (100% and 75%) were included. Various measurements were performed during the exercise sessions, of which heart rate, blood pressure, blood glucose, and lactate were obtained for this thesis. In addition, CHO intake during exercise and the average total daily bolus insulin dose were analyzed over the respective 14-day period. Data were tested for normal distribution using Shapiro-Wilk normality test and parameters were compared using paired t-test (p ≤ 0.05). For non-normally distributed data the non- parametric Friedman test was used (p ≤ 0.05). Results There was no statistically significant difference in heart rate (122.88 ± 15.91 vs. 122.94 ± 12.72; p = 0.91), systolic (148.9 ± 15.3 vs. 147.34 ± 15.32; p = 0.18) and diastolic (77.08 ± 5.04 vs. 77.37 ± 6.22; p = 0.93) blood pressure, lactate (2.03 ± 0.8 vs. 1.95 ± 0.61; p = 0.82), blood glucose (141.79 ± 17.69 vs. 141.4 ± 20.09; p = 0.61), CHO intake (27.48 ± 20.97 vs. 25.26 ± 18.29; p = 0.44) as well as the average total daily bolus insulin dose over the respective 14-day period (16.6 ± 10.66 vs. 15.7 ± 9.32; p = 0.28) between the 100% and 75% dosing scheme of IGlar U300. Conclusion No differences were observed in cardiac and metabolic response between 100% and 75% dosing of IGlar U300. These results may indicate that a reduction by 25% in basal insulin IGlar U300 has no immediate negative effects on the cardiovascular system, represented by blood pressure and heart rate, and the metabolism, represented by blood glucose levels and lactate during exercise.