Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Haidacher, F.
Oxidative stress and Anorexia nervosa
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2023. pp. 70
[OPEN ACCESS]
FullText
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Leal Garcia Sabrina
- Altmetrics:
- Abstract:
- Introduction The term oxidative stress refers to a disbalance of Reactive Oxygen Species (ROS) and the body’s anti-oxidative defense systems. Recently, the consequences of oxidative stress have become a central field of research and have been found to be linked to the genesis of multiple somatic as well as psychiatric diseases. In this pilot study, different potential links between markers of oxidative stress and the psychiatric condition Anorexia nervosa (AN) have been investigated. Methods The study included 40 participants (n=20 female patients with Anorexia nervosa (AN), n=20 healthy female participants (HC)). All participants completed multiple questionnaires regarding their eating habits (EAT-26, Eating Disorder Examination Questionnaire (EDEQ) and Mediterranean Diet Score (MDS)).To examine parameters of oxidative stress, blood tests were investigated for five different markers of oxidative stress (Total Oxidative Capacity (TOC), Total Antioxidative Capacity (TAC), Endogenous Peroxidase Activity (EPA), Autoantibodies against oxidized LDL (oLAb) and polyphenols (PPm)). Subsequently, the results were interpreted via SPSS. Results Compared with HCs, AN patients showed a significant reduction in TAC (t(34)=-2.181, p=0.36; AN: 1.47 (0.62); HC: 1.90 (0.56), for the other four parameters no significant differences were found between AN patients and the control group. Conclusion This study’s results indicate a significant reduction of the TAC in patients with AN in comparison to HCs. Further investigations including interventional studies, will be necessary to determine whether antioxidants can be used as add-on therapy in the treatment of AN.