Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rosenauer, I.
Die Rolle der Immunzellen bezüglich der Pathogenese von Endometriose: ein möglicher Therapieansatz?
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp. 82
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Heinemann Akos
- Luschnig Petra
- Altmetrics:
- Abstract:
- Endometriosis is a disease affecting many women worldwide. Despite the high incidence of endometriosis, little is known of its origin. Especially the etiology of endometriosis is not known yet, although many theories exist. Since changes of the immune cells in endometriosis have been observed, their role in the emergence and formation of the disease has been under discussion. In many studies, different types of immune cells have been proven to be increased or decreased in patients with endometriosis. The aim of this thesis was to find out if immune cells have an impact on the emergence of endometriosis. For this reason, the results of different publications were summarised and compared to determine, if there is a certain connection. This connection could be a target for medical therapy in the future, which highlights the importance of the analysis. In the center of attention are macrophages, lymphocytes, especially T-cells and natural killer cells. PubMed has been used as the main source of scientific research literature. The found studies have been divided by the different cell types and compared. Especially, studies showing differences in the quantity of immune cell types in endometriosis, regarding their function, indicates an important role of the immune system in endometriosis. In addition to that, a few studies including mouse models detected changes in endometriosis tissue after blocking different immune cell types or receptors interacting with immune cells. These studies indicate a promising treatment approach for the immune system in endometriosis.