Medizinische Universität Graz - Research portal
Selected Publication:
Bresilla, D.
Alterations of mitochondrial function during in vivo aging in nematodes and mice
[ Diplomarbeit/Master Thesis (UNI) ] TU Graz; 2022.
FullText
- Authors Med Uni Graz:
- Bresilla Doruntina
- Advisor:
- Madreiter-Sokolowski Corina
- Altmetrics:
- Abstract:
- Aging is associated with a decline in function and the occurrence of metabolic disorders. Fundamental research is essential to understand the mechanism of metabolic alterations and to reveal potential targets to counteract age-related cellular dysfunction. This work investigates aging in mice and nematodes. Mice tissue, including the brain, skeletal muscle, liver, lung, and heart, of female and male C57BL/6NRj mice aged 3, 6, 12, and 24 months have been analyzed with NMR spectroscopy to identify metabolic features of aging and sex-specific differences. The use of multivariate data analysis techniques revealed significant separation between the age groups in the distinct tissues. Besides, we identified the most prominently changing metabolites in female and male tissues. A refined analysis of individual metabolite levels during aging revealed a biphasic pattern for various metabolites in the brain, heart, liver, and lung. In contrast, a linear decrease of amino acids was apparent in muscle tissues. Numerous metabolite changes already occurred at six months. In addition, substantially sex-specific variations in regard to metabolites were identified in the liver. Notably, age-related alterations in C57BL/6NRj mice were substantially different from previously studied C57BL/6J mice, stressing the importance of selecting the appropriate strain for studying aspects of aging. (...)