Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Foessl, I.
From Morphology to Molecular Phenotyping –
miRNAs as novel biomarkers
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2022. pp. 107
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- Autor*innen der Med Uni Graz:
- Fößl Ines
- Betreuer*innen:
- Obermayer-Pietsch Barbara
- Altmetrics:
- Abstract:
- Phenotyping of complex diseases is a challenging task. The exact reasons for the development of many diseases still need to be understood. Chronic diseases are becoming more of a threat to individual patients as well as an additional burden to healthcare systems in general, which are already operating at their limits. Therefore, prognostic biomarkers are desirable to identify people at risk. Biomarkers are also essential for the diagnosis of diseases, the follow-up and the monitoring of treatment successes. In the process of clinical treatment decisions, biomarker assisted workflows promise evidence-based decisions, especially in cases where a treatment regimen is difficult to assess without such decision support. This thesis aims at trying to find solutions for new diagnostic and predictive biomarkers. The three thesis publications are dealing with different aspects of diagnostics and early detection of medical problems. The review publication by Foessl et al. can be seen as an exemplary model of how complex phenotyping is applied in today's clinical and research settings, taking bone phenotyping as an example. The research papers included in this thesis are two practical examples for different strategies of study design tailored to identify potential new miRNA biomarkers for two different types of diseases. While one publication is covering the topic of acute burn wounds the other publication deals with Hashimoto´s thyroiditis (HT), a chronic disease. Due to the different stages at which the research is currently at for both entities, the study designs were adapted for each topic. A general introduction and a discussion are framing the work for this cumulative thesis, which represents the scientific work done between October 2016 and January 2022 within the PhD programme DK-MOLIN.