Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Faschinger, F.
The impact of Sarcopenia on patients with colorectal liver metastasis undergoing partial hepatectomy.
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp. 61
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Imamovic Arvin
- Wagner Doris
- Altmetrics:
- Abstract:
- Introduction: Sarcopenia is described as generalized, age-related, progressive loss of muscle mass, muscle function, and, moreover, a surrogate parameter for the Frailty syndrome. It is associated with significantly higher morbidity and mortality. In most cases, Sarcopenia remains undiagnosed, although the social and economic damages plus the burden on our healthcare system can be estimated as remarkable. Methods: For our retrospective study, we used data from 342 patients undergoing partial hepatic resection due to colorectal, hepatic metastasis between 2005 and 2019. We compared non-sarcopenic with sarcopenic and sarcopenic obese patients. By measuring the preoperative muscle mass of patients at the height L3 with OSIRIX DICOM viewer using CT scans and calculating the Skeletal muscle Index (SMI), the presence of sarcopenia could be estimated. Results: 342 patients were included. Preoperative CT scans were available in 251 patients. We incorporated multiple parameters, especially turning our attention to overall survival. Overall survival in months between non-sarcopenic (63,6) and sarcopenic (49,5) patients differed significantly (p-value 0,01). However, after a Kaplan Meier analysis, a log-rank test was insignificant. (p-value 0,06) After another Kaplan Meier analysis, a further log-rank test comparing non-sarcopenic with sarcopenic obese patients in terms of postoperative survival in months showed a statistical significance (p-value 0,011). Generally, patients suffering from Sarcopenia or sarcopenic obesity died more frequently of disease during the observation period than non-sarcopenic patients. Discussion: Given the progressing obsolesce of the western population, the relevance of sarcopenia and its impact on health, economy, and our social system will rise rapidly. Our study showed a significant impact on the patient’s mortality and long-term survival apart from a few unclear parameters. The data matches the current literature and shows that measures to treat and prevent this condition must be taken as soon as possible.