Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aliabadi, A.
Cardiac biomarkers and their importance for the prognosis in peripheral arterial disease patients
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2022. pp. 53
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Gary Thomas
- Toth-Gayor Gabor
- Altmetrics:
- Abstract:
- Introduction: Peripheral arterial disease (PAD) is a manifestation of atherosclerosis that results in arterial stenoses and occlusions, predominantly in the lower extremities. Consequently, the perfusion is impaired, which manifests clinically as intermittent claudication and can progress to critical limb ischemia (CLI) with ischemic rest pain and tissue loss. Troponin and brain natriuretic peptide (BNP) are primarily cardiac biomarkers which play a crucial role in heart diseases such as myocardial infarction and heart failure, respectively. The subject of this diploma thesis is to evaluate the significance of these biomarkers for PAD. Methods: A retrospective study was conducted including 1743 patients who were treated at the Division of Angiology, Medical University of Graz. Collected data included age, sex, cardiovascular risk factors such as arterial hypertension and diabetes, and intake of antiplatelet drugs such as aspirin and clopidogrel. Additionally, several biomarkers were measured including C-reactive protein (CRP), troponin T, and BNP. In the following, the correlation between cardiac biomarkers and the occurrence of vascular endpoints including CLI, myocardial infarction (MCI), and stroke were analyzed by means of univariate and multivariate regression. Results: The study population was characterized by a mean age of 69.2 ± 11.9 years. 1046 men (60.0%) and 697 women (40.0%) were included in the study, arterial hypertension was present in 81.2% and diabetes in 33.2%. The study population for BNP was smaller and included 332 patients. Regression analyses showed statistical significance for CLI (univariate regression: troponin T p < 0.001, BNP p < 0.001; multivariate regression: troponin T p < 0.001). Troponin T > 0.01 ng/ml was associated with an OR of 2.439 (1.827 – 3.255) for CLI. Conclusion: Increased troponin T is significantly associated with patients with CLI. Troponin T measurement is an often-used test in the context of myocardial ischemia, however, it also appears to be associated with a more aggressive course of PAD.