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Wiester, M.
The impact of Nr4a1 on the dissemination of aggressive lymphoma.
[ Diplomarbeit/Master Thesis (UNI) ] TU Graz; 2022. pp.60.
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Autor*innen der Med Uni Graz:
Betreuer*innen:: Deutsch Alexander; Feichtinger Julia
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Abstract:: Aggressive lymphoma are a heterogeneous group and can further be divided into many different subgroups like Burkitt lymphoma, Burkitt like lymphoma, mantle cell lymphoma, and diffuse large B cell lymphoma (DLBCL). In general, aggressive lymphoma have a poor long-term survival rate. Therefore, researchers are looking for molecular mechanisms, that can serve as a target for novel therapies. In aggressive lymphomas, NR4A1 possesses tumor suppressive functions. In the EμMyc transgenic lymphoma mouse model, we observed that loss of Nr4a1 accelerates lymphomagenesis and a higher tumor cell infiltration of bone marrow and spleen. The aim of this study was to comprehensively study the impact of Nr4a1 loss on lymphoma dissemination. Therefore, we transplanted EμMyc Nr4a1-/- and EμMyc Nr4a1+/+ lymphoma cells into immune-competent as well as immunodeficient mice and determined lymphoma cell infiltration of the kidney, liver, brain, lung, spleen, thymus, and lymph node by histological examination. Furthermore, we determined the expression levels of the chemokine receptors and integrins in EμMyc Nr4a1-/- and EμMyc Nr4a1+/+ lymphomas by RQ-PCR. (...)