Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mueller, C.
Mechanisms of antibiotic resistance in gram-negative bacteria and their impact on health care in low-income countries
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2021. pp. 67
[OPEN ACCESS]
FullText
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Bärnthaler Thomas
- Luschnig Petra
- Altmetrics:
- Abstract:
- One of the most important achievements in medicine has been the discovery and development of antimicrobial drugs. However the rise of antibiotic resistance has reached an exceptional magnitude over the last few decades and is predicted to surpass cancer as the worldwide leading cause of death within the next thirty years. The clinical consequences of antibiotic resistance that we can see today and those we expect for the future encompass more than limited treatment of infection. They include a variety of health care and socio-economic associated problems that arise if global antibiotic resistance increases. The endangerment of common medical procedures and treatments such as caesarean sections and chemotherapy as well as an increase in disability-adjusted life years and exploding health care costs are among the list of consequences. To get a better understanding of the emergence and spread of antibiotic resistance the molecular resistance mechanisms must be examined and brought into context with the anthropogenic and environmental factors that influence antibiotic resistance. This thesis aims to summarize the structure and function of important molecular resistance mechanisms of gram-negative bacteria. Additionally it shines a light on the complex interplay between bacteria, humans and the environment. With low- and middle-income countries being especially endangered because of socio-economic characteristics that disadvantage the mitigation of antibiotic resistance the specific problems of these regions are discussed and possible starting points to better the situation are elaborated.