Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Somma, AW.
ECM1 and its role in cardiac remodelling after Myocardial Infarction.
[ Diplomarbeit/Master Thesis (UNI) ] Graz University of Technology
; 2021. pp.47.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Rainer Peter
- Altmetrics:
- Abstract:
- Heart diseases and their consequences are still the spearhead of the causes of death worldwide and therefore require special attention. Thanks to modern medicine, a large number of acute heart attacks can now be treated well, but many people still have to struggle with the sequelae after the onset of the heart attack. In some cases, the initial event can lead to cardiac fibrosis, which persistently and continuously weakens the heart muscle and ultimately leads to failure of the organ. Various amplifying signal transduction pathways are involved here. In my work I have tried to shed light on a key element of these signalling pathways and to record their changes. We are talking about the extracellular matrix protein 1. This is associated with fibrotic changes in the heart tissue and probably contributes significantly to the morphological changes in the heart muscle after a heart attack. To shed light on these in more detail, it was necessary to examine the underlying signal transduction pathways that are activated by ECM1. (...)