Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Plani, I.
Cardiac Dysfunction in Adolescents
with Type 1 Diabetes Mellitus
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2021. pp. 44
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Goswami Nandu
- Altmetrics:
- Abstract:
- Background: Cardiac abnormalities are known complications in adult with diabetes mellitus; however, wide gaps still exist in understanding the evolution of cardiac dysfunction in adolescents with type 1 diabetes mellitus (T1D). Aims and objectives: The aim of this diploma thesis is to carry out a literature review on the known effects of T1D in cardiac function in adolescents, as well as early therapeutic interventions and raise awareness on further research on the matter. Methodology: The review of the current literature included primary and secondary sources. Medical database was obtained from Pubmed. Inclusion criteria were studies conducted in the last 10 years, on humans, 8-18 years of age, written in English or German and with a free full text availability. Moreover, only publications about the cardiac function were included, whether studies about vascular function were excluded. Findings of recently published studies were systematically analyzed. Results and discussion: A total of 9 studies fulfilled the inclusion criteria. Analysis of the current literature showed that adolescents with T1D have left ventricle diastolic dysfunction, as well as left ventricle hypertrophy. The contradictory findings about the association of glycemic control with cardiac function in T1D adolescents, indicate that further research is required. A higher Body- Mass- Index is associated with a reduction of myocardial performance. Additional therapy with alpha-lipoic acid besides insulin, resulted in an increase of left ventricle function and decrease of several biochemical markers involved in the mechanism of hyperglycemic oxidative stress, which is responsible in the development of diabetic cardiomyopathy. Conclusions and future directions: Adolescents with T1D have early signs of the development of diabetic cardiomyopathy. Alpha lipoic-acid may play a role in its prevention. However, further research is needed on detection of cardiac abnormalities in adolescents with T1D, on understanding its mechanisms and on possible beneficial therapeutic interventions.