Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Charania, S.
The relationship between carotid intima-media thickness, serum biomarkers of cardiovascular disease, and HIV-infection in a South African study population.
[ Dissertation ] Stellenbosch University; 2021. pp.267.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Goswami Nandu
- Altmetrics:
- Abstract:
- Background: Brachial artery flow-mediated dilatation (FMD) and carotid artery intima-media thickness (IMT) are measures of vascular endothelial function and subclinical atherosclerosis respectively. Both endothelial dysfunction and subclinical atherosclerosis have been linked with HIV and antiretroviral therapy (ART) in the developed world. Furthermore, known biomarkers of inflammation and endothelial dysfunction can be measured to predict cardiovascular outcomes in HIV-infected individuals. The exact link between endothelial dysfunction, atherosclerosis, HIV, ART and the biomarkers remains inconclusive, particularly in South African and Western Cape populations.