Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Singer, E.
Irisin - a regulator of exercise induced effects on the “bone-muscle-unit”
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2021. pp. 57
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Gruber Hans-Jürgen
- Niedrist Tobias Josef
- Altmetrics:
- Abstract:
- Fairly new discovered in 2012, the hormone irisin could have an impact on many different areas of the human body. As it is released from the muscle during physical activity, it might help to explain the positive influence of exercise on peoples´ health. Former studies presented an expression of irisin depending on the intensity of exercise. In order to get a better understanding of the dynamics of irisin, we conducted a human pilot study with five middle-aged women as well as an animal study with 20 female Sprague-Dawley rats. Human and animal probands underwent a previously defined procedure of physical activity and blood draws were taken before and afterwards. Keeping in mind that the number of test persons was quite small, no statistically significant results could be found. Nevertheless, some correlations were detected: a moderate positive correlation between irisin levels and BMI as well as a moderate negative correlation between irisin and cholesterol levels. Sclerostin, another hormone taking part in bone metabolism was highly correlated with the age of probands. Regarding the animal study, exercising individuals gained significantly less weight compared to non-exercising ones. This even applied when a high fat diet was fed; animals of the exercising high fat diet group weighed statistically significant less than non-exercising animals (p=0,008). Those findings matched the data of former studies, which as well confirmed the weight-reducing effect of exercise. The conducted study could not determine the detailed kinetics of irisin but confirming information regarding exercise and weight gain as well as interesting correlations of sclerostin and age of probands could be found.