Medizinische Universität Graz - Research portal
Selected Publication:
Simcikas, D.
Impact of sulforaphane on FOLFOX induced toxicity to human colon cancer cells
[ Dissertation ] Universitaet Heidelberg; 2015.
FullText
- Authors Med Uni Graz:
- Advisor:
- Schemmer Peter
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- Abstract:
- Colorectal cancer is a major health problem. Liver is the most common site of CRC metastases, which extremely worsen the prognoses of patients. When possible, surgical resection is the standard of care for liver metastases, however the majority of metastases are initially non-resectable or never likely to be resectable. At least 50% of all CRC patients receive chemotherapy in the attempt to palliate unresectable disease or downstage lesions making patients eligible for surgery and reduce the risk of recurrence after surgery. FOLFOX is widely used established standard chemotherapy for advanced CRC. However, unwanted side effects, namely hematologic, neurologic, digestive, general toxicity, as well as relapses and metastases after the treatment, limit successful therapeutic outcome of FOLFOX based regimens. It is therefore important to investigate new drug combinations to obtain higher efficacy and reduce side effects of chemotherapy. Phytochemical sulforaphane is a promising candidate for combination therapy due to its chemopreventive properties and cytotoxicity to different cancer types. Pharmacokinetic studies of SF in animal and human show good dietary absorption and distribution in the body reaching therapeutic concentration in target tissues.(...)